Modeling aging and retinal degeneration with mitochondrial DNA mutation burden.
J. Sturgis, R. Singh, Q. Caron, I. S. Samuels, T. M. Shiju, A. Mukkara, P. Freedman, V. L. Bonilha
This study uses a POLG deficiency model to show that mtDNA mutations cause retinal degeneration through impaired mitochondrial function and accelerated aging.
bioRxiv · Nov 30, 2023Cell Biology