Correlating surface plasmon resonance microscopy of living and fixated cells with electron microscopy allows for investigation of potential preparation artifacts
E. Kreysing, S. Seyock, H. Hassani, E. Brauweiler-Reuters, E. Neumann, A. Offenhaeusser
The paper quantifies the impact of chemical fixation on the cell-substrate interface using SPRM and EM, showing fixation preserves distances and identifies preparation artifacts.
bioRxiv · Oct 24, 2019Biophysics