Population based selection shapes the T cell receptor repertoire during thymic development
F. Camaglia, A. Ryvkin, E. Greenstein, S. Reich-Zeliger, B. Chain, T. Mora, A. M. Walczak, N. Friedman
The paper studies how thymic selection shapes the TCR repertoire during T cell development and finds that selection acts statistically rather than through specific sequence suppression.
bioRxiv · Feb 14, 2022Immunology