N. Friedman

A dominant role of TGFβ in regulating T-cell size and physiology

This study shows TGFβ profoundly regulates T-cell size and physiology by modulating gene expression and transcription factor networks, independent of other cytokines.

Molecular mechanisms underlying the modulation of T-cell proliferation and cytotoxicity by immobilized CCL21 and ICAM1

This study investigates how a synthetic immune niche modulates T-cell proliferation and cytotoxicity, finding that these properties are negatively correlated and differentially regulated by activation mode.

Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain

This paper develops and validates new tools for multi-organ neuroimaging of neural and vascular dynamics in the brain and spinal cord, including 3D-printed implants and bioluminescent imaging.

Epigenetic liquid biopsies reveal elevated vascular endothelial cell turnover and erythropoiesis in asymptomatic COVID-19 patients

This study uses epigenetic liquid biopsies to show that asymptomatic COVID-19 patients have elevated vascular endothelial cell and erythroblast turnover, indicating sub-clinical vascular and erythrocyte damage.

Modulating the proliferative and cytotoxic properties of human TIL by a synthetic immune niche of immobilized CCL21 and ICAM1

This study shows that a synthetic immune niche with CCL21 and ICAM1 enhances TIL expansion and cytotoxicity in vitro and in vivo.

Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes

This study uses cfChIP-seq on plasma samples to subtype SCLC based on epigenetic states, linking plasma nucleosome data to tumor transcriptomes and developing a classifier for lineage-defining transcription factors.

Conserved degronome features governing quality control-associated proteolysis

The paper identifies conserved degron features in yeast, viruses, and humans that govern quality control proteolysis, showing transmembrane domain-like sequences are key determinants of protein half-life.

Population based selection shapes the T cell receptor repertoire during thymic development

The paper studies how thymic selection shapes the TCR repertoire during T cell development and finds that selection acts statistically rather than through specific sequence suppression.

Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma

The paper investigates OMAS in neuroblastoma, finding polyclonal B- and T-cell infiltration and TLS enrichment, linking them to autoimmune and anti-tumor responses.

Transcription feedback dynamics in the wake of cytoplasmic degradation shutdown

This study investigates how cells adapt to Xrn1 depletion by monitoring mRNA and nascent mRNA dynamics, revealing a transcriptional response linked to cell cycle progression.

Antigen experience relaxes the organisational structure of the T cell receptor repertoire

The paper examines how antigen exposure affects the structural organization of T cell receptor repertoires in mice across different life stages and infection states.

The proteasome regulator PSME4 drives immune evasion and abrogates anti-tumor immunity in NSCLC

This paper identifies PSME4 as a proteasome regulator that suppresses anti-tumor immunity in NSCLC by inhibiting immunoproteasome activity and antigen presentation.

Transcriptomic profiling of human corona virus (HCoV)-229E -infected human cells and genomic mutational analysis of HCoV-229E and SARS-CoV-2

This study uses transcriptomic analysis to identify cellular pathway changes in HCoV-229E-infected cells and links APOBEC3B activity to genomic mutations in SARS-CoV-2.

Influenza virus inhibits respiratory syncytial virus (RSV) infection via a two-wave expression of interferon-induced protein with tetratricopeptide (IFIT) proteins

This study shows influenza virus inhibits RSV infection through a two-wave upregulation of IFIT proteins, observed in both in vitro and in vivo models.

Miniaturized Devices for Bioluminescence Imaging in Freely Behaving Animals

This paper demonstrates a modified fluorescent miniscope capable of detecting bioluminescence in vivo with improved sensitivity and reduced hardware complexity.

Endocrine autoimmune disease as a fragility of immune-surveillance against hypersecreting mutants

This paper proposes a theory that endocrine autoimmune diseases arise from a fragility in immune surveillance against hypersecreting mutant cells.

Temporal profiling of redox-dependent heterogeneity in single cells

The paper tracks redox status in yeast cells at single-cell resolution, identifies redox-dependent subpopulations, and identifies key proteins involved in redox homeostasis.