LRRK2 kinase inhibitors induce a reversible effect in the lungs of non-human primates with no measurable pulmonary deficits
M. Baptista, K. Merchant, T. Barrett, D. Bryce, M. Ellis, A. Estrada, M. Fell, B. Fiske, R. Fuji, P. Galatsis, A. Henry, S. Hill, W. Hirst, C. Houle, M. Kennedy, , T. Sherer
This study evaluates the lung effects of LRRK2 kinase inhibitors in non-human primates, finding reversible histopathological changes without pulmonary function deficits.
bioRxiv · Aug 15, 2018 · PreprintPharmacology & Toxicology