Global and local mechanical properties control endonuclease reactivity of a DNA origami nanostructure
A. Suma, A. Stopar, A. W. Nicholson, M. Castronovo, V. Carnevale
This study uses molecular dynamics simulations to show that global and local mechanical properties of DNA origami influence endonuclease reactivity, with structural defects increasing accessibility to restriction enzymes.
bioRxiv · Jan 27, 2020Biophysics