Author

V. Carnevale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 9 Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:protein folding & dynamics· 5 Approach:biophysical modeling· 3 Organism:human· 3 Approach:mechanistic / dynamical model· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. A. Kasimova· 4 shared T. Rohacs· 4 shared A. Suma· 3 shared A. T. Yazici· 2 shared D. Cabezas-Bratesco· 2 shared D. Granata· 2 shared E. Gianti· 2 shared S. E. Brauchi· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiophysics

M. A. Kasimova

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11 papers

Recent·Most cited

Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore module

K. Schott, S. G. Usher, O. Serra, V. Carnevale, S. Pless, H. C. Chua

This paper identifies a hidden drug binding site in NALCN by unplugging its lateral fenestrations and shows that 2-APB and phenytoin access the pore through distinct pathways.

bioRxiv · Apr 12, 2023 · PreprintPharmacology & Toxicology

Computational and functional characterization of the PI(4,5)P2 binding site of the TRPM3 ion channel

S. Zhao, V. Carnevale, E. Gianti, T. Rohacs

This study identifies PI(4,5)P2 binding residues in TRPM3 and shows their role in channel regulation and interactions with ligands and G{beta}{gamma}.

bioRxiv · Jun 5, 2022 · PreprintBiophysics

Sequence conservation and structural features that are common within TRP channels

D. Cabezas-Bratesco, C. K. Colenso, K. Zavala, D. Granata, V. Carnevale, J. C. Opazo, S. E. Brauchi

The paper identifies a conserved residue fingerprint in TRP channels that may explain differences in coupling strategies among subgroups.

bioRxiv · Sep 6, 2021Evolutionary Biology

The biophysical basis of protein domain compatibility

W. Coyote-Maestas, D. Nedrud, A. Suma, Y. He, K. A. Matreyek, D. M. Fowler, V. Carnevale, C. L. Myers, D. Schmidt

The paper uses high-throughput assays and machine learning to model biophysical interactions governing protein domain compatibility in fusion proteins.

bioRxiv · Dec 9, 2020 · PreprintBiophysics

The propofol binding sites of prokaryotic voltage-gated sodium channels

E. C. Yang, W. Bu, A. Suma, V. Carnevale, K. Grasty, P. Loll, K. Woll, N. Bhanu, B. A. Garcia, R. G. Eckenhoff, M. Covarrubias

This study identifies conserved propofol binding sites in prokaryotic voltage-gated sodium channels and shows how conformational changes at these sites mediate propofol's effects on channel function.

bioRxiv · Oct 28, 2020 · PreprintBiophysics

Global and local mechanical properties control endonuclease reactivity of a DNA origami nanostructure

A. Suma, A. Stopar, A. W. Nicholson, M. Castronovo, V. Carnevale

This study uses molecular dynamics simulations to show that global and local mechanical properties of DNA origami influence endonuclease reactivity, with structural defects increasing accessibility to restriction enzymes.

bioRxiv · Jan 27, 2020Biophysics

Phosphoinositides regulate the TRPV1 channel via two functionally distinct binding sites

A. T. Yazici, E. Gianti, M. A. Kasimova, V. Carnevale, T. Rohacs

This study resolves a controversy about TRPV1 regulation by showing phosphoinositides act through two distinct binding sites, one inhibitory and one activating.

bioRxiv · Feb 22, 2019 · PreprintBiophysics

Structural insights on TRPV5 gating by endogenous modulators

T. E. T. Hughes, R. A. Pumroy, A. T. Yazici, M. A. Kasimova, E. C. Fluck, K. W. Huynh, A. Samanta, S. Molugu, Z. H. Zhou, V. Carnevale, T. Rohacs, V. Y. Moiseenkova-Bell

The paper determines TRPV5 structures with endogenous modulators PI(4,5)P2 and CaM, revealing their mechanisms of activation and inhibition.

bioRxiv · Jul 31, 2018Biophysics

Conformational Dynamics In TRPV1 Channels Reported By An Encoded Coumarin Amino Acid

X. Steinberg, M. A. Kasimova, D. Cabezas-Bratesco, J. Galpin, E. Ladron de Guevara, F. Villa, V. Carnevale, L. D. Islas, C. A. Ahern, S. E. Brauchi

This study uses a genetically encoded fluorescent amino acid to monitor conformational changes in TRPV1 channels, showing that Y671 fluorescence correlates with channel activation by capsaicin.

bioRxiv · May 14, 2017Biophysics

TRPV1 activation relies on hydration/dehydration of nonpolar cavities

M. A. Kasimova, A. Yazici, Y. Yudin, D. Granata, M. L. Klein, T. Rohacs, V. Carnevale

The paper investigates TRPV1 gating mechanisms using simulations and electrophysiology, finding that hydration of nonpolar cavities is critical for channel opening and temperature sensitivity.

bioRxiv · May 5, 2017Biophysics

Free energy calculations suggest a mechanism for Na+/K+-ATPase ion selectivity

A. M. Razavi, L. Delemotte, J. R. Berlin, V. Carnevale, V. A. Voelz

The paper uses molecular simulations to identify a mechanism for Na+/K+-ATPase ion selectivity changes during conformational transitions.

bioRxiv · Feb 7, 2017Biophysics