DNA methylation is indispensable for leukemia inhibitory factor dependent embryonic stem cells reprogramming
B. Wu, Y. Li, B. Li, B. Zhang, Y. Wang, L. Li, G. Peng, Y. Fu, S. Li, C. Chen, A. Surani, F. Tang, X. Li, S. Bao
This study shows that LIF alone can reprogram 2i/LIF cultured ESCs to hypermethylated ESCs, demonstrating DNA methylation's essential role in LIF-dependent reprogramming and self-renewal.
bioRxiv · Mar 17, 2020 · PreprintCell Biology