ImmunologybioRxiv
Functionally Convergent B Cell Receptor Sequences in Transgenic Rats Expressing a Human B Cell Repertoire in Response to Tetanus Toxoid and Measles Antigens
J.-P. Buerckert, A. R. S. X. Dubois, W. J. Faison…·C. P. Muller
The paper shows that transgenic rats expressing human Ig develop convergent IgH sequences in response to various antigens, and presents a computational method to identify antigen-induced IgH signatures.
DOI 10.3389/fimmu.2017.01834