Functionally Convergent B Cell Receptor Sequences in Transgenic Rats Expressing a Human B Cell Repertoire in Response to Tetanus Toxoid and Measles Antigens
J.-P. Buerckert, A. R. S. X. Dubois, W. J. Faison, S. Farinelle, E. Charpentier, R. Sinner, A. Wienecke-Baldacchino, C. P. Muller
The paper shows that transgenic rats expressing human Ig develop convergent IgH sequences in response to various antigens, and presents a computational method to identify antigen-induced IgH signatures.
bioRxiv · Jul 13, 2017Immunology