Intercellular interaction between FAP fibroblasts and CD150 inflammatory monocytes mediates fibro-stenosis in Crohn's disease
B.-J. Ke, S. Abdurahiman, F. Biscu, G. Dragoni, S. Santhosh, V. De Simone, A. Zouzaf, L. van Baarle, M. Stakenborg, V. Bosakova, Y. Van Rymenant, E. Verhulst, S. Verstockt, G. Bislenghi, A. Wolthuis, , G. Matteoli
The paper identifies intercellular interactions between FAP fibroblasts and CD150 monocytes that drive fibro-stenosis in Crohn's disease and shows TWIST1 inhibition can reduce fibrosis.
bioRxiv · May 4, 2023Immunology