Efficient variance components analysis across millions of genomes
Ali Pazokitoroudi, Yue Wu, Kathryn S. Burch, Kangcheng Hou, Aaron Zhou, Bogdan Paşaniuc, Sriram Sankararaman
The paper introduces an efficient algorithm for variance components analysis, enabling rapid estimation of hundreds of variance components across large genomic datasets and demonstrating its utility in heritability estimation and functional annotation partitioning.
Nature Communications · Aug 11, 2020Peer-reviewedBioinformatics