Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy
Jonathan Rodriguez, Abdon Iniguez, Nilamani Jena, Prasanthi V. Tata, Zhongying Liu, Arthur D. Lander, John S. Lowengrub, Richard A. Van Etten
This paper develops a nonlinear mathematical model of CML hematopoiesis to predict TKI therapy responses and identifies strategies to improve treatment outcomes.
eLife · Apr 28, 2023Peer-reviewedSystems Biology