Arthur D. Lander

This study identifies two cell-of-origin-driven subtypes of BRCA1-associated TNBC, showing that tumor subtype depends on the cell type initiating the cancer.

The paper introduces a statistically principled feature selection method for scRNA-seq that improves accuracy in identifying rare cell types compared to existing tools.

This study shows that combined haploinsufficiency of Nipbl and Isl1 in mice leads to more severe congenital heart defects than either gene deficiency alone.

The paper shows that Hh signaling provides robustness to some target genes but not others, revealing tradeoffs between robustness and precision in morphogen gradient patterning.

The paper introduces BigSur, a method for identifying gene-gene correlations in scRNA-seq data without normalization, showing it captures significant correlation structures and aligns with known biological processes.

The paper investigates how 3D genome organization, specifically through Cohesin, influences gene co-expression in single cells and reveals its role in maintaining long-range chromatin interactions.

The paper identifies gene expression changes in Nipbl+/- mouse embryos during gastrulation that link Nipbl-deficiency to birth defects via mesoderm lineage misallocation and Nanog overexpression.

The paper develops an imaging pipeline to quantify 3D cellular proliferation and morphology during mouse facial development, showing their tight correlation.

This paper develops a nonlinear mathematical model of CML hematopoiesis to predict TKI therapy responses and identifies strategies to improve treatment outcomes.

This study shows that reducing Wapl dosage partially corrects transcriptome and growth defects in Nipbl-/+ embryonic mouse brains, suggesting cohesin dynamics regulate gene expression.

MusMorph provides standardized mouse morphology data for meta-analyses, including craniofacial and brain structures across developmental stages and genotypes.

The paper investigates how Dpp morphogen gradients scale in Drosophila wing discs and proposes an alternative feedback model to explain scaling failure in mutants.

This paper uses mathematical modeling to show that spatially uniform nonlocal feedback mechanisms can enhance robustness in signaling gradients, offering a new theoretical approach for promoting stable signaling.

This study identifies NIPBL's interaction with RNA and treacle in regulating pre-rRNA transcription and nucleolar organization.

This study examines how Nipbl haploinsufficiency affects cohesin binding and gene expression in mice, linking reduced cohesin function to CdLS-related gene dysregulation.