Recombinant SIRT1 expression and SIRT1-METTL3 interaction analysis with computational identification of phytochemical SIRT1 activators and inhibitors
Md Kazy Ebnul Hasan, Md. Nahid Hasan Joy, Liqing Lin, Md. Sanowar Hossan, Shahad Shahriar, Md. Mahedi Hasan Sourov, Md. Naymur Rahman, Md. Faruk Hasan, Md. Enamul Haque, Abdullah Al-Jubayer, Mamudul Hasan Razu, Md. Samiul Islam, Mengqi Lv, Yunyu Shi
This study identifies phytochemical SIRT1 activators and inhibitors through protein expression, purification, and computational modeling, revealing Catechin and Ginsenosides as promising therapeutic candidates.
bioRxiv · Oct 21, 2026 · PreprintMolecular Biology