Evaluating variant effect prediction across viruses
Sarah F. Gurev, Noor Youssef, Navami Jain, Aarushi Mehrotra, Sarrah Rose Mikhail Leung, Abigail Jackson, Debora S. Marks
This paper evaluates variant effect prediction models on viruses, showing that state-of-the-art models underperform on viral proteins compared to alignment-based models, especially in low-sequence regimes.
bioRxiv · Aug 4, 2025 · PreprintBioinformatics