Author

Noor Youssef

Broad InstituteORCID 0000-0002-7708-982XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 2 Organism:virus· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Debora S. MarksiD· 2 shared Sarah F. GureviD· 2 shared Aarushi Mehrotra· 1 shared Abigail Jackson· 1 shared Ben KotzeniD· 1 shared Jacob E. LemieuxiD· 1 shared Javier A. JaimesiD· 1 shared Jeremy LubaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersEvolutionary Biology

Debora S. MarksORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Transition from infectivity and immune escape to pure escape as an evolutionary strategy during the COVID-19 pandemic.

Ben Kotzen, Sarah F. Gurev, Noor Youssef, Javier A. Jaimes, Jeremy Luban, Debora S. Marks, Michael S. Seaman, Jacob E. Lemieux

The paper models SARS-CoV-2 evolution during the pandemic, finding that immune escape became more important than infectivity as variants evolved.

bioRxiv · Feb 27, 2026 · PreprintEvolutionary Biology

Evaluating variant effect prediction across viruses

Sarah F. Gurev, Noor Youssef, Navami Jain, Aarushi Mehrotra, Sarrah Rose Mikhail Leung, Abigail Jackson, Debora S. Marks

This paper evaluates variant effect prediction models on viruses, showing that state-of-the-art models underperform on viral proteins compared to alignment-based models, especially in low-sequence regimes.

bioRxiv · Aug 4, 2025 · PreprintBioinformatics