Unravelling the plausible metal-dependent catalytic mechanism of Inositol monophosphatase ortholog from Pseudomonas aeruginosa through the lenses of macromolecular crystallography and enzyme kinetics
Vinay Kumar Yadav, Abinash Kumar Jena, Mitali Mukerji, Amit Mishra, Sudipta Bhattacharyya
This study determines the crystal structures of PaIMPase and proposes three Mg2+-dependent catalytic mechanisms based on structural and kinetic analyses.
bioRxiv · Apr 6, 2026 · PreprintBiophysics