Spinal microglia are dispensable for the development of opioid-induced hyperalgesia
Julia E.R. Nickols, Tom Wilson, Kelly V. Lee, Jayme M Clark, Adam C Wass, Charbel S. Baaklini, Christian A. Faig, Madelene F.S. Ho, Katherine M. Souter, Bożena Szulc, Marianela Evelyn Traetta, Jason R. Plemel, Anna M.W. Taylor
This study shows that spinal microglia are not required for opioid-induced hyperalgesia, analgesic tolerance, or withdrawal symptoms in mice.
bioRxiv · Sep 30, 2026 · PreprintNeuroscience