Jason R. Plemel

This study shows that spinal microglia are not required for opioid-induced hyperalgesia, analgesic tolerance, or withdrawal symptoms in mice.

The paper investigates microglial dynamics and modulation in MS models using siponimod, showing reduced neuronal damage and changes in microglial markers.

This study shows that senescent microglia impair remyelination in young mice but not aged mice, with CCL11 in SASP inhibiting oligodendrocyte maturation.

This study shows that human CD33 isoforms differentially affect microglial responses in Alzheimer's disease, with CD33m showing protective effects against amyloid-beta pathology.

This study investigates how social isolation affects microglia structure and neural activity in specific brain regions of male and female mice, revealing region- and sex-specific changes.