Transcriptional bursting explains the noise-versus-mean relationship in mRNA and protein levels
Roy D. Dar, Sydney M. Schaffer, Siddarth S. Dey, Jonathan E. Foley, Abhyudai Singh, Brandon S. Razooky, Adam P. Arkin, David V. Schafer, Michael L. Simpson, Arjun Raj, Leor S. Weinberger
The paper re-examines HIV LTR mRNA and protein expression data, finding that noise scales inversely with mean expression, supporting the inverse correlation between noise and mean.
bioRxiv · Apr 21, 2016Systems Biology