Brandon S. Razooky

A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

Self-organized stem cell-derived human lung buds with proximo-distal patterning and novel targets of SARS-CoV-2

This paper describes a platform to generate human lung buds from stem cells that mimic lung development and are susceptible to SARS-CoV-2 infection, revealing alveolar cell vulnerability and potential therapeutic targets.

TMEM41B is a pan-flavivirus host factor

The paper identifies TMEM41B as a host factor required for flavivirus infection and shows SNPs in TMEM41B reduce infection in East Asian populations.

Non-latching positive feedback enables robust bimodality by de-coupling expression noise from the mean

The paper investigates how HIV's Tat protein generates bimodal expression through non-latching positive feedback, decoupling noise from mean expression to maintain stochastic bimodality.

Transcriptional bursting explains the noise-versus-mean relationship in mRNA and protein levels

The paper re-examines HIV LTR mRNA and protein expression data, finding that noise scales inversely with mean expression, supporting the inverse correlation between noise and mean.