The mechanical code of DNA impacts its interaction with DNA gyrase
Bailey G. Forbes, Rosella Pinckney, Sisi Liu, Aditi Biswas, Heather Potter, Elizabeth R. Morris, Aakash Basu
The paper shows that DNA sequence-encoded mechanical properties influence DNA gyrase binding by modulating DNA wrapping around its CTDs, revealing asymmetric interactions and GC-rich motifs that enhance binding.
bioRxiv · Oct 21, 2025 · PreprintBiophysics