Aakash Basu

Live E. coli gyrase clusters hold excess GyrB (B:A 2.5:1), show hexanediol-sensitive liquid-like turnover, and docking suggests GyrB bridges heterotetramers.

The paper develops a statistical mechanics approach to identify sequence features controlling DNA cyclizability, finding periodic features in highly cyclizable sequences and distinct patterns in low cyclizability.

The paper shows that DNA sequence-encoded mechanical properties influence DNA gyrase binding by modulating DNA wrapping around its CTDs, revealing asymmetric interactions and GC-rich motifs that enhance binding.

This study shows DNA anisotropy encodes nucleosome formation mechanics and codon usage optimizes DNA structure around nucleosomes.

This paper develops a computational model to predict DNA mechanics from sequence, revealing mechanical selection in diverse eukaryotes and identifying extreme DNA mechanics in nature.