Ultrastructural and Histological Cryopreservation of Mammalian Brains by Vitrification
Gregory M. Fahy, Ralf Spindler, Brian G. Wowk, Victor M Vargas, Richard La, Bruce Thomson, Roberto I. Roa, Hugh Hixon, Steve Graber, Xian Ge, Adnan Sharif, Steven B. Harris, L. Stephen Coles
This paper demonstrates that mammalian brains can be cryopreserved by vitrification without prior aldehyde fixation, preserving ultrastructural integrity and showing potential for human cryopreservation.
bioRxiv · Feb 14, 2026 · PreprintNeuroscience