Cystine/glutamate antiporter system Xc- deficiency impairs insulin secretion.
Axel De Baat, Daniel T. Meier, Leila Rachid, Adriano Fontana, Marianne Böni‐Schnetzler, Marc Yves Donath
This study shows that Slc7a11 deficiency reduces glutathione levels and impairs insulin secretion in beta-cells but not in islet macrophages.
bioRxiv · Jan 19, 2023 · PreprintMolecular Biology