Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo
Philip McGoldrick, Agnes Lau, Zhipeng You, Thomas M. Durcan, Janice Robertson
This study shows that loss of C9orf72 disrupts the Ran-GTPase gradient and creates diverse cytoplasmic Importin β-1 granules in neurons, linking it to nucleocytoplasmic transport defects.
bioRxiv · Oct 20, 2021 · PreprintNeuroscience