Aberrant iron deposition in the multiple sclerosis spinal cord relates to neurodegeneration
Marco Pisa, Andrew Lockhart, Thomas Angell, Aimee Avery, Alex D. Waldman, Carla Rodriguez, Tiago L. Duarte, Jonathan Pansieri, Zaenab Dhari, Mary A. Bailey, Simon Hametner, Hal Drakesmith, Monika Hofer, Clara Limbӓck-Stanic, Gabriele Carmine DeLuca
This study shows that iron accumulates abnormally in the spinal cord of MS patients, correlating with oxidative stress and neurodegeneration, but not with demyelination or iron-rimmed lesions.
bioRxiv · Oct 25, 2024 · PreprintNeuroscience