Characterization of Somatic Mutations in Human tRNA Genes Reveals Tumor-Specific Mutational Loads, and the Generation of tRNA Variants that Alter the Genetic Code
Marina Murillo-Recio, Marina Salvadores, Adrián Gabriel Torres, Lina Tsapanou, Aina Vaquer Picó, Fran Supek, Lluı́s Ribas de Pouplana
The paper characterizes somatic mutations in human tRNA genes, showing they are mutagenesis hotspots with tumor-specific loads and can generate altered tRNA variants affecting the genetic code.
bioRxiv · Jun 9, 2025 · PreprintGenomics