This study shows that Chlamydia trachomatis infection causes global histone hypermethylation by inhibiting demethylation, leading to altered transcription and affecting infection outcomes.

eLife · Sep 14, 2026Peer-reviewedCell Biology

Characterization of Somatic Mutations in Human tRNA Genes Reveals Tumor-Specific Mutational Loads, and the Generation of tRNA Variants that Alter the Genetic Code

Marina Murillo-Recio, Marina Salvadores, Adrián Gabriel Torres, Lina Tsapanou, Aina Vaquer Picó, Fran Supek, Lluı́s Ribas de Pouplana

The paper characterizes somatic mutations in human tRNA genes, showing they are mutagenesis hotspots with tumor-specific loads and can generate altered tRNA variants affecting the genetic code.

bioRxiv · Jun 9, 2025 · PreprintGenomics

AARS Online: a collaborative database on the structure, function, and evolution of the aminoacyl-tRNA synthetases

Jordan Douglas, Haissi Cui, John J. Perona, Oscar Vargas‐Rodriguez, Henna Tyynismaa, Claudia Álvarez-Carreño, Jiqiang Ling, Lluı́s Ribas de Pouplana, Xiang‐Lei Yang, Michael Ibba, Hubert Becker, Frédéric Fischer, Marie Sissler, Charles W. Carter, Peter R. Wills

AARS Online provides a curated database of aminoacyl-tRNA synthetases with sequence, structure, and evolutionary information, accessible via an interactive platform.

IUBMB Life · Sep 9, 2024Peer-reviewedBiochemistry

Subcellular relocalization and nuclear redistribution of the RNA methyltransferases TRMT1 and TRMT1L upon neuronal activation

Nicky Jonkhout, Sonia Cruciani, Helaine Graziele Santos Vieira, Julia Tran, Huanle Liu, Ganqiang Liu, Russell Pickford, Dominik C. Kaczorowski, Glória Regina Franco, Franz Vauti, Noelia Camacho, Seyedeh Sedigheh Abedini, Hossein Najmabadi, Lluı́s Ribas de Pouplana, Daniel Christ, , Eva Maria Novoa

The paper investigates the subcellular relocalization of TRMT1 and TRMT1L during neuronal activation and identifies their role in RNA modification dynamics and neuronal plasticity.

RNA Biology · Jan 27, 2021Peer-reviewedMolecular Biology