OxLDL-targeted Chimeric Antigen Receptor T Regulatory Cells Reduce Atherosclerotic Plaque Development
Robert D. Schwab, David A. Degaramo, Seok Jae Hong, Xin Bi, Aisha Faruqi, William Aguilar, Shawna K. Brookens, John T. Keane, Fang Liu, Kiran Musunuru, Daniel James Rader, Avery D. Posey
This study develops anti-OxLDL CAR Tregs that reduce atherosclerotic plaque formation in mice by targeting OxLDL-mediated inflammation.
Circulation · Nov 21, 2025Peer-reviewedSynthetic Biology