Lipoengineering of Biomolecular Condensates Controls Material Properties and Multiphase Hierarchy to Guide Organoid Morphogenesis
Zhiwei Huang, Md. Mahbub Alam, Mahtab Shokri, Harshavardhan Chilukuri Savitrinarayana, Valappil Sisila, Tanushree Agarwal, Rob M. Scrutton, Laiba Maryam, Asma Gulzar, Jinying Wang, Dominic J. Tigani, Liege Aguiar Pascoalino, Akshay V. Jadhav, Albert Lawrence Adhya, Alaji Bah, , Davoud Mozhdehi
This study uses lipidation to control biomolecular condensate properties and interactions, enabling the creation of multi-phase hydrogels that guide intestinal organoid morphogenesis.
bioRxiv · Apr 10, 2026 · PreprintBioengineering