Cytoglobin-dependent NO-sGC-cGMP signaling regulates ventricular morphogenesis and diastolic function.
Adam Austin Clark, Rasmus Hejlesen, Tzu-Ting Weng, Muddassar Iqbal, Akueba Bruce, Paola Corti
This study shows that Cygb-dependent NO-sGC-cGMP signaling is critical for ventricular development and function, and its disruption leads to HLHS-like features in zebrafish.
bioRxiv · Jul 16, 2026 · PreprintDevelopmental Biology