Single-base substitutions switch RNA tertiary allostery between positive and negative coupling.
Alabi Oladeji, Brandon G. Kircher, Joseph David Yesselman
The paper identifies single-base substitutions that switch RNA tertiary allostery between positive and negative coupling using a minimal 3D-structure ligand-inducible switch.
bioRxiv · Aug 11, 2026 · PreprintBiochemistry