Joseph David Yesselman

The paper identifies single-base substitutions that switch RNA tertiary allostery between positive and negative coupling using a minimal 3D-structure ligand-inducible switch.

The paper analyzes DMS reactivity patterns in RNA constructs to characterize 3D structural features and find correlations with hydrogen bonding and solvent accessibility.

This study quantitatively characterizes the thermodynamics of RNA nanostructure self-assembly, showing sensitivity to environmental conditions and distinct melting temperatures for tertiary and secondary structures.

The paper introduces local stability compensation (LSC) as a principle governing RNA folding, showing it is prevalent in RNA structures and validated through chemical mapping experiments.

This paper introduces qDMS-MaPseq, a high-throughput method to measure RNA tertiary contact thermodynamics using DMS chemical mapping, showing strong correlation with specialized instruments.