Mapping Light-Induced Conformational Dynamics of Pigeon Cryptochrome 4 by HDX-MS: Structural Transitions from Spin Pair Formation to Activated Conformational States
Gargi S. Jagdale, Victoria Fan, Priyanka Dubey, Alan Pham, Emily Jiang, Anthony T. Iavarone, Judith Pollock Klinman
This study uses HDX-MS and spectroscopy to analyze light-induced structural changes in pigeon CRY4, revealing conformational dynamics linked to radical-pair chemistry and magnetoreception.
bioRxiv · Sep 1, 2026 · PreprintBiophysics