Structural basis and mechanism of action of NrdR, a bacterial master regulator of ribonucleotide reduction
Lucas Pedraz, Arkadiusz Szura, Claus Schmitz, Alba Rubio-Canalejas, Anthony Santella, Gabriel Gomila, Annalisa Calò, Marı́a Solà, Eduard Torrents
This study elucidates the structural basis and mechanism of NrdR, a bacterial regulator of ribonucleotide reduction, showing how nucleotides modulate its quaternary structure and activity.
bioRxiv · Mar 28, 2025 · PreprintMolecular Biology