Anthony Santella

Transient morphogenetic constraints organize self-assembling axon neighborhoods for robust yet flexible wiring

The paper shows how transient morphogenetic structures and stochastic innervation models shape reproducible yet flexible wiring in C. elegans nervous systems through a trade-off between physical constraints and molecular specificity.

A Single-cell Spatiotemporal Manifold of Tissue Morphology and Dynamics

This paper introduces a learned single-cell spatiotemporal manifold to analyze tissue morphology and dynamics over time.

A tumor metabolism-angiogenesis-immune axis governs immunotherapy responses

This study shows that reducing tumor glycolysis improves immunotherapy responses by normalizing the tumor microenvironment and enhancing immune cell activity.

Structural basis and mechanism of action of NrdR, a bacterial master regulator of ribonucleotide reduction

This study elucidates the structural basis and mechanism of NrdR, a bacterial regulator of ribonucleotide reduction, showing how nucleotides modulate its quaternary structure and activity.

Automated Cell Lineage Reconstruction using Label-Free 4D Microscopy

This paper introduces embGAN, a deep learning pipeline for automated cell detection and tracking in label-free 3D time-lapse imaging without manual annotation.

Cross-modality Synthesis of EM Time Series and Live Fluorescence Imaging

The paper develops a cross-modality image alignment method to integrate EM and fluorescence imaging data in C. elegans, revealing dynamic cell behaviors during nervous system development.

Differential adhesion regulates neurite placement via a retrograde zippering mechanism

The paper investigates how differential adhesion controls neurite placement in C. elegans brain neuropils through a retrograde zippering mechanism.

Structural and developmental principles of neuropil assembly in C. elegans

The paper uses diffusion condensation to analyze the C. elegans nerve ring neuropil, revealing its stratified structure and developmental principles.

Cadherin Preserves Cohesion Across Involuting Tissues During C. elegans Neurulation

This study shows that HMR-1/Cadherin mediates tissue cohesion during C. elegans neurulation, suggesting a potential homology with vertebrate neurulation.

Multicellular rosettes organize neuropil formation

The paper shows multicellular rosettes organize the nerve ring neuropil in C. elegans by guiding axon outgrowth and structural formation.

Cellular structure image classification with small targeted training samples

The paper presents a deep learning method using GANs and feature transfer to classify cell shapes with minimal training samples, achieving high accuracy in detecting multicellular rosettes in C. elegans embryos.