The asymmetric Pitx2 regulates intestinal muscular-lacteal development and protects against fatty liver disease
Shing Hu, Aparna Mahadevan, Isaac F. Elysee, Joseph Choi, Nathan R. Souchet, Gloria H. Bae, Alessandra Taboada, Bhargav D. Sanketi, Gerald E. Duhamel, Carolyn S. Sevier, Ge Tao, Natasza A. Kurpios
The paper identifies the role of asymmetric Pitx2 in intestinal lacteal development and shows its protective effect against fatty liver disease through lymphatic-dependent lipid transport.
Cell Reports · Nov 1, 2021Peer-reviewedDevelopmental Biology