Author

Alessandro G. Franchini

University of Zurich

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1

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Dorothea M. HeubergeriD· 1 shared Jerzy MadoniD· 1 shared Reto Andreas SchuepbachiD· 1 shared

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2019-2019 · peak 1/yr

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1 shared paperMolecular Biology

Dorothea M. HeubergerORCID

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1 paper

Recent·Most cited

Thrombin cleaves and activates the protease-activated receptor 2 dependent on thrombomodulin co-receptor availability

Dorothea M. Heuberger, Alessandro G. Franchini, Jerzy Madon, Reto Andreas Schuepbach

This study shows thrombin cleaves PAR2 in a TM-dependent manner, leading to NF-κB activation and interleukin-8 release, suggesting a pro-inflammatory role for TM.

Thrombosis Research · Feb 28, 2019Peer-reviewedMolecular Biology