Evidence of epistasis in regions of long-range linkage disequilibrium across five complex diseases in the UK Biobank and eMERGE datasets
Pankhuri Singhal, Yogasudha Veturi, SCOTT M. DUDEK, Anastasia Lucas, Alex Frase, Kristel Van Steen, Steven J. Schrodi, David A. Fasel, Chunhua Weng, Rion K. Pendergrass, Daniel J. Schaid, Iftikhar J. Kullo, Ozan Dikilitas, Patrick M. Abou‐Sleiman, Hakon H. Hakonarson, , Shefali S. Verma
The paper identifies epistatic SNP-SNP interactions in long-range LD across five diseases using UK Biobank and eMERGE data, finding associations involving conserved genes and essential genes.
The American Journal of Human Genetics · Apr 1, 2023Peer-reviewedGenetic & Genomic Medicine