Author

Alex J. Wolf

Michigan State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Research Focus:benchmarking· 1 Approach:machine learning (classical)· 1 Research Focus:protein structure prediction· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Joseph Bemister-Buffington· 2 shared Leslie A. KuhniD· 2 shared Sebastian RaschkaiD· 2 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersBioinformatics

Joseph Bemister-Buffington

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2 papers

Recent·Most cited

Machine Learning to Identify Flexibility Signatures of Class A GPCR Inhibition

Joseph Bemister-Buffington, Alex J. Wolf, Sebastian Raschka, Leslie A. Kuhn

The paper uses machine learning to identify flexibility signatures in GPCRs that distinguish active from inactive states based on ligand-induced structural changes.

Biomolecules · Mar 14, 2020Peer-reviewedBioinformatics

Protein-ligand interfaces are polarized: Discovery of a strong trend for intermolecular hydrogen bonds to favor donors on the protein side with implications for predicting and designing ligand complexes

Sebastian Raschka, Alex J. Wolf, Joseph Bemister-Buffington, Leslie A. Kuhn

The paper identifies a strong trend in protein-ligand interactions where proteins prefer to donate hydrogen bonds and ligands accept them, leading to the development of tools to predict and design ligand complexes.

Journal of Computer-Aided Molecular Design · Feb 11, 2018Peer-reviewedBioinformatics