An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish
Madyson M. McCarthy, Makenna J. Hardy, Saylor E. Leising, Alex M. LaFollette, Erica S. Stewart, Amelia S. Cogan, Tanya Sanghal, Katie Matteo, Jonathon C. Reeck, Julia Thom Oxford, Troy T. Rohn
This study shows that an amino-terminal fragment of APOE4 causes behavioral deficits, increased tau pathology, and mortality in zebrafish.
PLoS ONE · Dec 15, 2022Peer-reviewedNeuroscience