One score to rule them all: regularized ensemble polygenic risk prediction with GWAS summary statistics
Zijie Zhao, Stephen Dorn, Yuchang Wu, Xiaoyu Yang, Alexander Beckerman, Jin Jin, Qiongshi Lu
This paper introduces a statistical framework for regularized ensemble polygenic risk prediction using GWAS summary statistics, showing improved performance across traits and populations.
bioRxiv · Nov 27, 2024 · PreprintGenetics