Xiaoyu Yang

This paper introduces a statistical framework for regularized ensemble polygenic risk prediction using GWAS summary statistics, showing improved performance across traits and populations.

This study introduces PENGUIN, a framework to control genetic confounding in epidemiologic studies, showing it effectively removes confounding in educational attainment associations.

The paper identifies functional CREs in iPSCs and neurons and links them to neuropsychiatric disease risk variants.

This study introduces S-BEAM, a semi-supervised ensemble method to prioritize non-coding variants and their target genes in microglia for Alzheimer's disease, identifying 11 risk variants and proposing 37 for further study.

The paper identifies 491,818 candidate cis regulatory elements in adult mouse brain sub-types and links them to target genes and transcriptional regulators involved in various pathways.

The study identifies TMEM132D's role in neuronal morphogenesis through interaction with NAP1 and the WAVE regulatory complex in C. elegans.

This study characterizes 3D epigenomic landscapes during human corticogenesis, revealing chromatin looping and super interactive promoters involved in lineage-specific gene regulation.

The paper identifies cis-regulatory chromatin contacts in neural cells and links them to genetic variants associated with complex neurological disorders.