Cohesin erases genomic-proximity biases to drive stochastic Protocadherin expression for proper neural wiring
Lea Alice Kiefer, Gabrielle Isabelle F. Servito, Sandy M. Rajkumar, Jennifer Langen, Anna Chiosso, Alexander Buckley, S. Elizabeth, Adan Horta, Michael H. Mui, Daniele Canzio
The paper reveals cohesin's role in enabling stochastic Protocadherin expression in olfactory sensory neurons by regulating enhancer-promoter interactions and DNA demethylation, contrasting with deterministic expression in serotonergic neurons.
bioRxiv · Mar 9, 2022 · PreprintGenomics