The Clonal Hematopoiesis-associated Gene Srcap Plays an Essential Role in Hematopoiesis
Terrence Wong, Anna Mychalowych, Ellie R. Feldpausch, Alexander Carson, Darja Karpova, Daniel C. Link
This study shows that Srcap is essential for normal hematopoiesis, HSC function, and genomic integrity, with loss of Srcap causing DNA damage and p53 pathway activation.
bioRxiv · Aug 16, 2024 · PreprintCell Biology