Phenotypic Differences in Adult and Fetal Dermal Fibroblast Responses to Mechanical Tension
Walker D. Short, Umang M. Parikh, Natalie Templeman, Oluyinka O. Olutoye, Alexander J. Blum, Daniel Colchado, Benjamin W. Padon, Aditya Kaul, Hui Li, Hima V. Vangapandu, Olivia S. Jung, Pranav Bommekal, Phillip Kogan, Monica M. Fahrenholtz, Cristian Coarfa, Swathi Balaji
This study compares how mechanical tension affects HA metabolism and fibrotic gene expression in fetal and adult dermal fibroblasts, showing distinct responses that may explain differences in wound healing outcomes.
bioRxiv · Sep 30, 2020 · PreprintMolecular Biology