Endothelial Adgrl2 expression and alternative splicing controls the cerebrovasculature
Alexander King, Catherine Garcia, Crisylle Blanton, Anna Chen, Amna Ahmad, David Lukacsovich, Csaba Földy, Takako Makita, Garret R. Anderson
The paper shows that Adgrl2 alternative splicing generates distinct isoforms in neurons and endothelial cells, with neuronal isoform expression in endothelial cells altering cerebrovascular properties and blood-brain barrier integrity.
Journal of Neuroscience · Mar 24, 2026Peer-reviewedNeuroscience