Takako Makita

Endothelial Adgrl2 expression and alternative splicing controls the cerebrovasculature

The paper shows that Adgrl2 alternative splicing generates distinct isoforms in neurons and endothelial cells, with neuronal isoform expression in endothelial cells altering cerebrovascular properties and blood-brain barrier integrity.

Adrenergic Hypersensitivity Drives Ventricular Arrhythmias Following Loss of Plexin-Mediated Cardiac Innervation

This study shows that loss of plexin-mediated cardiac innervation leads to adrenergic hypersensitivity and ventricular arrhythmias in mice, with human PLXNA4 variants linked to arrhythmias.

Placode and neural crest origins of congenital deafness in mouse models of Waardenburg-Shah syndrome

This study investigates the role of endothelin signaling in auditory development using mouse models of Waardenburg-Shah syndrome, revealing distinct contributions from neural crest and placode lineages.

Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development

The paper shows that two distinct ENS progenitor lineages use endothelin signaling differently to support migration to the hindgut.

Bowel dysmotility and enteric neuron degeneration in lysosomal storage disease mice is prevented by gene therapy

This paper shows gene therapy prevents bowel motility issues and enteric neuron loss in mouse models of lysosomal storage diseases.

Purkinje cardiomyocytes of the ventricular conduction system are highly diploid but not regenerative

The paper identifies Purkinje cardiomyocytes as a diploid subpopulation in the ventricular conduction system that lacks regenerative capacity despite their diploid status.